Document Detail


Pharmacokinetic-hemodynamic studies of disopyramide.
MedLine Citation:
PMID:  6199608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic effects and pharmacokinetics of two doses of disopyramide (DP) given as a two-stage intravenous load and maintenance infusion were studied in anesthetized dogs. One group (n = 4) received 4 mg/kg for 30 min and 1 mg/kg/h for 30 min (low-dose group). The high-dose group (n = 4) received 8 mg/kg for 30 min and 4 mg/kg/h for 30 min. In the low-dose group, there was a fall in cardiac output which reached statistical significance at 300 min [from 3.4 +/- 0.4 (SD) to 2.7 +/- 0.7 L/min; p less than 0.05, analysis of variance (ANOVA)]. In the high-dose group, there also was a fall in cardiac output (from 4.6 +/- 1.4 to 3.0 +/- 0.4 L/min; p less than 0.01, ANOVA), and this was associated with a rise in total peripheral resistance (from 39 +/- 11 to 58 +/- 9 units; p less than 0.01). Peak total venous DP concentrations were 3.0 +/- 0.2 and 7.5 +/- 1.0 micrograms/ml for the low- and high-dose groups, respectively, and were achieved at the end of the load infusion. The free fraction of DP was not dependent on total venous DP concentration and approximated 0.66. Elimination half-life, clearance, and apparent volume of distribution were 3.91 +/- 0.53 h, 0.39 +/- 0.02 L/kg/h, and 2.22 +/- 0.32 L/kg, respectively, for the low-dose group and 3.67 +/- 0.91 h, 0.36 +/- 0.06 L/kg/h, and 1.84 +/- 0.29 L/kg, respectively, for the high-dose group. There were no significant differences between these measurements for low- versus high-dose groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H Abdollah; J F Brien; P W Armstrong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-03-29     Completed Date:  1984-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Output / drug effects
Disopyramide / metabolism,  pharmacology*
Dogs
Half-Life
Hemodynamics / drug effects*
Kinetics
Time Factors
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
3737-09-5/Disopyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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