Document Detail

Pharmacokinetic factors in the clinical use of tryptophan.
MedLine Citation:
PMID:  6512006     Owner:  NLM     Status:  MEDLINE    
A patient with chronic pain and DSM-III unipolar and cyclothymic disorders was treated with L-tryptophan, 3000 mg before bed for 3 nights, and showed no response. She then began to take L-tryptophan, 1000 mg every 4 hours, with a high carbohydrate, low protein meal and immediately showed a clear improvement in exercise tolerance (reduced pain) and alleviation of affective symptoms. The importance of pharmacokinetic factors in the clinical use of L-tryptophan is emphasized.
R J Hedaya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  4     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-8     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Cyclothymic Disorder / drug therapy
Depressive Disorder / drug therapy
Pain / drug therapy
Tryptophan / administration & dosage,  metabolism,  therapeutic use*
Reg. No./Substance:

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