Document Detail


Pharmacokinetic evaluation of the terfenadine-theophylline interaction.
MedLine Citation:
PMID:  2493044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on results of studies of a possible terfenadine-theophylline interaction on file with Merrell Dow, Inc., a randomized, crossover study was undertaken to determine if there were a pharmacokinetic interaction between these two medications. Seventeen normal volunteers were randomized to receive theophylline or a theophylline-terfenadine combination for 14 days, followed by a 2-week washout period, with crossover to the other treatment for 14 days. Serum theophylline concentrations were measured on the last day of each treatment phase for determination of pharmacokinetic parameters. No differences were found in elimination rate constant, elimination half-life, area under the concentration-time curve, time to peak concentration, or maximum theophylline concentration. It is concluded that concomitant terfenadine therapy does not affect the pharmacokinetic profile of theophylline in healthy male volunteers.
Authors:
S S Luskin; W E Fitzsimmons; C M MacLeod; A T Luskin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  83     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-03     Completed Date:  1989-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  406-11     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacy, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.
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MeSH Terms
Descriptor/Qualifier:
Adult
Benzhydryl Compounds / adverse effects,  blood,  pharmacokinetics*
Drug Administration Schedule
Drug Combinations
Drug Interactions
Follow-Up Studies
Humans
Male
Random Allocation
Terfenadine
Theophylline / adverse effects,  blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Drug Combinations; 50679-08-8/Terfenadine; 58-55-9/Theophylline
Comments/Corrections
Erratum In:
J Allergy Clin Immunol 1989 Jun;83(6):1082

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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