| Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy. | |
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MedLine Citation:
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PMID: 11408245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the pharmacokinetics (PK) profile of oral levofloxacin in human immunodeficiency virus-positive patients in steady-state treatment with nelfinavir (NFV) or with efavirenz (EFV) and to determine the effects of levofloxacin on the PK parameters of these two antiretroviral agents. For levofloxacin, plasma samples were obtained at steady state during a 24-h dosing interval. Plasma NFV and EFV concentrations were evaluated before and after 4 days of levofloxacin treatment. Levofloxacin PK do not seem affected by NFV and EFV. There was no significant difference between NFV and EFV plasma levels obtained with and without levofloxacin. |
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Authors:
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P Villani; P Viale; L Signorini; B Cadeo; F Marchetti; A Villani; C Fiocchi; M B Regazzi; G Carosi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 45 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-15 Completed Date: 2001-10-04 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 2160-2 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anti-HIV Agents / pharmacology, therapeutic use Anti-Infective Agents / pharmacokinetics* Benzoxazines Cohort Studies Drug Interactions HIV Infections / drug therapy, metabolism* Humans Nelfinavir / pharmacology, therapeutic use Ofloxacin / pharmacokinetics* Oxazines / pharmacology, therapeutic use Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Anti-Infective Agents; 0/Benzoxazines; 0/Oxazines; 154635-17-3/efavirenz; 159989-64-7/Nelfinavir; 82419-36-1/Ofloxacin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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