Document Detail


Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy.
MedLine Citation:
PMID:  11408245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the pharmacokinetics (PK) profile of oral levofloxacin in human immunodeficiency virus-positive patients in steady-state treatment with nelfinavir (NFV) or with efavirenz (EFV) and to determine the effects of levofloxacin on the PK parameters of these two antiretroviral agents. For levofloxacin, plasma samples were obtained at steady state during a 24-h dosing interval. Plasma NFV and EFV concentrations were evaluated before and after 4 days of levofloxacin treatment. Levofloxacin PK do not seem affected by NFV and EFV. There was no significant difference between NFV and EFV plasma levels obtained with and without levofloxacin.
Authors:
P Villani; P Viale; L Signorini; B Cadeo; F Marchetti; A Villani; C Fiocchi; M B Regazzi; G Carosi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  45     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-10-04     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2160-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Anti-HIV Agents / pharmacology,  therapeutic use
Anti-Infective Agents / pharmacokinetics*
Benzoxazines
Cohort Studies
Drug Interactions
HIV Infections / drug therapy,  metabolism*
Humans
Levofloxacin*
Nelfinavir / pharmacology,  therapeutic use
Ofloxacin / pharmacokinetics*
Oxazines / pharmacology,  therapeutic use
Prospective Studies
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Anti-Infective Agents; 0/Benzoxazines; 0/Oxazines; 6GNT3Y5LMF/Levofloxacin; A4P49JAZ9H/Ofloxacin; HO3OGH5D7I/Nelfinavir; JE6H2O27P8/efavirenz
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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