| Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion. | |
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MedLine Citation:
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PMID: 84204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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15 cases of cimetidine-associated mental confusion have been reported. In order that this syndrome might be investigated changes in mental status (M.S.) were correlated with serum concentrations and renal and hepatic function in 36 patients, 30 patients had no M.S. change on cimetidine and 6 had moderate to severe changes. These 6 patients had both renal and liver dysfunction (P less than 0.05), as well as cimetidine trough-concentrations of more than 1.25 microgram/ml (P less than 0.05). The severity of M.S. changes increased as trough-concentrations rose, 5 patients had lumbar puncture. The cerebrospinal fluid: serum ratio of cimetidine concentrations was 0.24:1 and indicates that cimetidine passes the blood-brain barrier; it also raises the possibility that M.S. changes are due to blockade of histamine H2-receptors in the central nervous system. Patients likely to have both raised trough-concentrations and mental confusion are those with both severe renal and hepatic dysfunction. They should be closely observed and should be given reduced doses of cimetidine. |
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Authors:
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J J Schentag; F B Cerra; G Calleri; E DeGlopper; J Q Rose; H Bernhard |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-04-28 Completed Date: 1979-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cimetidine / adverse effects*, cerebrospinal fluid, metabolism, therapeutic use Cognition Disorders / chemically induced* Confusion / chemically induced* Female Gastrointestinal Hemorrhage / drug therapy Guanidines / adverse effects* Humans Kidney / drug effects*, physiopathology Liver / drug effects*, physiopathology Mental Processes / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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