Document Detail


Pharmacokinetic alteration in rats of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2.
MedLine Citation:
PMID:  8069264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the pharmacokinetic alteration in rats of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Serum rIL-2 levels after the intravenous administration of the immune complex at a dose of 100 micrograms/rat as rIL-2 were significantly higher than those after intravenous administration of rIL-2 alone at the same dose. Pharmacokinetic analysis indicated that the distribution volume of rIL-2 decreased from 74.0 to 10.3 ml/rat, while the elimination rate of rIL-2 was little changed by immunocomplexing with the antibody. On the other hand, serum rIL-2 levels after the subcutaneous administration of the immune complex at a dose of 100 micrograms/rat as rIL-2 were sustained longer than those after the subcutaneous administration of rIL-2 alone at the same dose, and Tmax shifted from 0.83 to 3.0 h by immunocomplexing with the antibody. Pharmacokinetic analysis also revealed that the mean-residence-time of rIL-2 increased from 1.98 to 6.52 h, and the area-under-the curve of rIL-2 decreased slightly, from 834 to 548 ng.h/ml, by immunocomplexing with the antibody.
Authors:
J Sato; N Hamaguchi; K Doken; S Iwasa; Y Ogawa; H Toguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-26     Completed Date:  1994-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  IM    
Affiliation:
DDS Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / metabolism*
Antigen-Antibody Complex
Cells, Cultured
Injections, Intravenous
Injections, Subcutaneous
Interleukin-2 / administration & dosage,  blood,  immunology,  pharmacokinetics*
Male
Rats
Rats, Sprague-Dawley
Recombinant Proteins / pharmacokinetics
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigen-Antibody Complex; 0/Interleukin-2; 0/Recombinant Proteins

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