| Pharmacokinetic Allometric Scaling of Oligonucleotides. | |
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MedLine Citation:
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PMID: 21916609 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the predictive performance of interspecies scaling of oligonucleotides to predict clearance and volume of distribution at steady state in humans from animal data. The human pharmacokinetic parameters were predicted using 1, 2, or at least 3 animal species. The results of the study indicated that the pharmacokinetic parameters of oligonucleotides can be predicted with reasonable accuracy in humans when at least 3 animal species are employed. On the other hand, allometric scaling based on 1 or 2 species or fixed coefficient or fixed exponent can be erratic and unreliable. Further work should be conducted in this direction. |
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Authors:
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Iftekhar Mahmood |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
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Title: Nucleic acid therapeutics Volume: - ISSN: 2159-3345 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101562758 Medline TA: Nucleic Acid Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research , Food & Drug Administration, Rockville, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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