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Pharmacogenomics in heart failure: where are we now and how can we reach clinical application?
MedLine Citation:
PMID:  25093738     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heart failure is becoming increasingly prevalent in the United States and is a significant cause of morbidity and mortality. Several therapies are currently available to treat this chronic illness; however, clinical response to these treatment options exhibit significant interpatient variation. It is now clearly understood that genetics is a key contributor to diversity in therapeutic response, and evidence that genetic polymorphisms alter the pharmacokinetics, pharmacodynamics, and clinical response of heart failure drugs continues to accumulate. This suggests that pharmacogenomics has the potential to help clinicians improve the management of heart failure by choosing the safest and most effective medications and doses. Unfortunately, despite much supportive data, pharmacogenetic optimization of heart failure treatment regimens is not yet a reality. In order to attenuate the rising burden of heart failure, particularly in the context of the recent paucity of new effective interventions, there is an urgent need to extend pharmacogenetic knowledge and leverage these associations in order to enhance the effectiveness of existing heart failure therapies. This review focuses on the current state of pharmacogenomics in heart failure and provides a glimpse of the aforementioned future needs.
Authors:
Akinyemi Oni-Orisan; David E Lanfear
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology in review     Volume:  22     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:    2014 Sep-Oct
Date Detail:
Created Date:  2014-08-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
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