| Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes. | |
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MedLine Citation:
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PMID: 20177288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether functional maternal or fetal genotypes along well-characterized metabolic pathways (ie, CYP1A1, GSTT1, and CYP2A6) may account for varying associations with adverse outcomes among pregnant women who smoke. METHODS: DNA samples from 502 smokers and their conceptuses, alongside women in a control group, were genotyped for known functional allelic variants of CYP1A1 (Ile462Val AA>AG/GG), GSTT1(del), and CYP2A6 (Lys160His T>A). Modification of the association between smoking and outcome by genotype was evaluated. Outcomes included birth weight, pregnancy loss, preterm birth, small for gestational age, and a composite outcome composed of the latter four components plus abruption. RESULTS: No interaction between maternal or fetal genotype of any of the polymorphisms and smoking could be demonstrated. In contrast, the association of smoking with gestational age-adjusted birth weight (birth weight ratio) was modified by fetal GSTT1 genotype (P for interaction=.02). Fetuses with GSTT1(del) had a mean birth weight reduction among smokers of 262 g (P=.01), whereas in fetuses without the GSTT1(del) the effect of tobacco exposure was nonsignificant (mean reduction 87 g, P=.16). After adjusting for confounding, results were similar. CONCLUSION: Fetal GSTT1 deletion significantly and specifically modifies the effect of smoking on gestational age-corrected birth weight. |
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Authors:
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Kjersti Aagaard-Tillery; Catherine Y Spong; Elizabeth Thom; Baha Sibai; George Wendel; Katharine Wenstrom; Philip Samuels; Hyagriv Simhan; Yoram Sorokin; Menachem Miodovnik; Paul Meis; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 115 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-23 Completed Date: 2010-03-17 Revised Date: 2012-01-24 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 568-77 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA. aagaardt@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aryl Hydrocarbon Hydroxylases
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genetics Case-Control Studies Cytochrome P-450 CYP1A1 / genetics Female Fetal Growth Retardation / genetics* Gene Deletion Genotype Glutathione Transferase / genetics* Humans Infant, Low Birth Weight* Infant, Newborn Polymorphism, Single Nucleotide* Pregnancy Pregnancy Complications / genetics* Prospective Studies Smoking / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DP2 OD001500-01/OD/NIH HHS; L40 HD051105-05/HD/NICHD NIH HHS; U01-HD36801/HD/NICHD NIH HHS; U10-HD21410/HD/NICHD NIH HHS; U10-HD21414/HD/NICHD NIH HHS; U10-HD27860/HD/NICHD NIH HHS; U10-HD27861/HD/NICHD NIH HHS; U10-HD27869/HD/NICHD NIH HHS; U10-HD27905/HD/NICHD NIH HHS; U10-HD27915/HD/NICHD NIH HHS; U10-HD27917/HD/NICHD NIH HHS; U10-HD34116/HD/NICHD NIH HHS; U10-HD34122/HD/NICHD NIH HHS; U10-HD34136/HD/NICHD NIH HHS; U10-HD34208/HD/NICHD NIH HHS; U10-HD34210/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 1.14.14.1/coumarin 7-hydroxylase; EC 2.5.1.-/glutathione S-transferase T1; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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