| Pharmacogenetics and schizophrenia. | |
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MedLine Citation:
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PMID: 20832661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The wide interindividual variability in clinical response and tolerability of antipsychotic medications has led investigators to postulate that these variabilities may be under genetic control. Although not always consistent, there are promising indications from emergent pharmacogenetic studies that efficacy of antipsychotic medications for the various symptom domains of psychopathology in schizophrenia may be genetically regulated. This is an encouraging approach. Moreover, there are also suggestive findings that the side-effect profiles of second-generation antipsychotic medications and their propensity to cause weight gain and glucose and lipid abnormalities as well as tardive dyskinesia may be related to pharmacogenetic factors in this patient population. Ultimately, such approaches could drive choices of antipsychotic medication based on the likelihood of clinical response and development of side effects in light of a particular patient's genetic profile. In the future, this targeted approach (personalized medicine) may become informative for clinicians choosing an antipsychotic medication for an individual patient with schizophrenia. |
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Authors:
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Adriana Foster; Del D Miller; Peter Buckley |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 30 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-10 Revised Date: 2011-09-08 |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 975-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 St Sebastian, Augusta, GA 30912, USA. afoster@mcg.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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pharmacology,
therapeutic use Genetic Testing Humans Individualized Medicine Pharmacogenetics* Schizophrenia / drug therapy*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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