Document Detail


Pharmacogenetics of oral anticoagulants.
MedLine Citation:
PMID:  16093729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of oral anticoagulants (OA) is problematic due to its association with hemorrhagic complications. OA metabolism relies on the CYP2C9 complex. Genetic variations compromising metabolic competence of this complex may explain the risk of excessive and hazardous anticoagulation. A pharmacogenetics-based approach to this issue could be beneficial for choosing adequate dose and duration of treatment, in addition to having a better understanding of pharmacological interactions to which OA are susceptible. However, evidence from several basic and clinical studies indicates that both a complicated system of regulation of expression of multiple genes and the influence of a wide variety of epigenetic factors could be responsible for adverse drug reactions associated with the use of OA. Emphasis on understanding the gene-environment interactions could attain new paths to facilitate the use of these important drugs in the quotidian clinical practice.
Authors:
Julio César Rojas; Bernardo Aguilar; Emma Rodríguez-Maldonado; María Teresa Collados
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  16     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2006-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  389-98     Citation Subset:  IM    
Affiliation:
Center for Research and Extension in Health Sciences, Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo Leon, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anticoagulants / administration & dosage,  adverse effects,  pharmacokinetics*
Aryl Hydrocarbon Hydroxylases / genetics*
Biotransformation / genetics
Epigenesis, Genetic*
Gene Expression Regulation / drug effects
Humans
Pharmacogenetics
Chemical
Reg. No./Substance:
0/Anticoagulants; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C9 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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