Document Detail

Pharmacogenetics and individual variation in the range of amino acid adequacy: the biological aspects.
MedLine Citation:
PMID:  15173437     Owner:  NLM     Status:  MEDLINE    
There have been major developments in our understanding of the ways in which genetic variation among individuals in a population can affect responses to drugs, and use of such information can improve the safety and efficacy of medicines. The brief review summarizes the emergence of modern pharmacogenetics, illustrating the importance of the field using the CYP 2D6 polymorphism as a paradigm. These pharmacogenetic polymorphisms are compared and contrasted with the long-established inborn errors of amino acid biochemistry, exemplified by phenylketonuria, suggesting ways in which the approaches of pharmacogenetics might inform the safe and effective use of amino acids as food additives and supplements.
John Caldwell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2004-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1600S-1604S; discussion 1630S-1632S, 1667S-1672S     Citation Subset:  IM    
The University of Liverpool, Liverpool L69 3GA, UK.
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MeSH Terms
Amino Acid Metabolism, Inborn Errors / genetics
Amino Acids* / metabolism
Biological Transport
Cytochrome P-450 CYP2D6 / genetics
Drug Therapy
Genetic Variation*
Nutritional Requirements
Nutritional Status / genetics*
Phenylketonurias / genetics
Polymorphism, Genetic
Reg. No./Substance:
0/Amino Acids; EC P-450 CYP2D6

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