| Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort. | |
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MedLine Citation:
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PMID: 19663678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the effects of genetic variation on treatment response to asthma medication in children and to identify (profiles of) SNPs that characterize response phenotypes. MATERIAL & METHODS: The Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects (PACMAN) study was initiated in April 2009 as an observational retrospective pharmacy-based study, including at least 1000 children with asthma medication (aged 4-12 years). Data on respiratory symptoms and medication use behavior will be collected using a questionnaire; complete medication histories will be extracted from the pharmacy information system; additional health information will be requested from the general practitioner; quality of inhalation technique and lung function measurements will be performed and saliva samples for DNA extraction and genotyping will be collected. Two groups of patients will be defined based on questionnaire data and lung function measurements: responders and nonresponders to anti-inflammatory asthma treatment. These two groups will be compared with respect to genetic variation. Corrections will be made for potential confounding factors. RESULTS: The main study end point is treatment response, including asthma control, medication use and exhaled nitric oxide as a measure of airway inflammation. Whilst our focus is on genetic factors, this study allows us to also investigate other treatment response determinants, such as inhalation technique and therapy adherence. CONCLUSION: Results from the PACMAN study could eventually lead to a more individualized therapy approach. PACMAN will focus on pharmacogenetics of asthma medication in children, while knowledge will be gained of relevant interest to the treatment of the asthma population at large. |
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Authors:
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Ellen S Koster; Jan Am Raaijmakers; Gerard H Koppelman; Dirkje S Postma; Cornelis K van der Ent; Leo Koenderman; Madelon Bracke; Anke Hilse Maitland-van der Zee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacogenomics Volume: 10 ISSN: 1744-8042 ISO Abbreviation: Pharmacogenomics Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897350 Medline TA: Pharmacogenomics Country: England |
Other Details:
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Languages: eng Pagination: 1351-61 Citation Subset: IM |
Affiliation:
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Utrecht University, Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, 3508 TB Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenal Cortex Hormones / administration & dosage, pharmacokinetics, therapeutic use Anti-Asthmatic Agents / administration & dosage, pharmacokinetics, therapeutic use* Anti-Inflammatory Agents / administration & dosage, pharmacokinetics, therapeutic use Asthma / drug therapy*, genetics* Child Child, Preschool Clinical Trials as Topic Cohort Studies Cross-Sectional Studies Humans Leukotriene Antagonists / administration & dosage, pharmacokinetics, therapeutic use Netherlands Pharmacogenetics / methods* Pilot Projects Polymorphism, Genetic* Questionnaires Respiratory Function Tests Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Leukotriene Antagonists |
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