Document Detail


Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction.
MedLine Citation:
PMID:  20712525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Genetic variability within the SLCO1B1 and ABCB1 transporter genes has been associated with modification of statin effectiveness in cholesterol management.
MATERIALS & METHODS: We conducted a case-control study using a population-based registry of pharmacy records linked to the hospital discharge records. Within a hypercholesterolemic cohort, we included 668 myocardial infarction cases and 1217 controls.
RESULTS: We tested 24 tagging SNPs and found two SNPs within ABCB1 (rs3789244, p = 0.01; rs1922242, p = 0.01) to interact with statin treatment. In addition, we found a nonsignificant haplotype-treatment interaction (p = 0.054). The odds ratio for subjects homozygous for SLCO1B1*1A was 0.49 (95% CI: 0.34-0.71) compared with 0.31 (95% CI: 0.24-0.41) for heterozygous or noncarriers of the *1A allele.
CONCLUSION: This is the first study to demonstrate that common genetic variability within the SLCO1B1 and ABCB1 genes is associated with the modification of the effectiveness of statins in the prevention of the clinical outcome, myocardial infarction.
Authors:
Bas J M Peters; Andrei S Rodin; Olaf H Klungel; Cornelia M van Duijn; Bruno H Ch Stricker; Ruben van't Slot; Anthonius de Boer; Anke-Hilse Maitland-van der Zee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacogenomics     Volume:  11     ISSN:  1744-8042     ISO Abbreviation:  Pharmacogenomics     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897350     Medline TA:  Pharmacogenomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  1065-76     Citation Subset:  IM    
Affiliation:
Faculty of Science, Division of Pharmacoepidemiology & Pharmacotherapy, Utrecht University, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Haplotypes
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  therapeutic use*
Incidence
Logistic Models
Male
Medical Records
Middle Aged
Myocardial Infarction / epidemiology,  genetics,  prevention & control*
Organic Anion Transporters / genetics*
P-Glycoprotein / genetics*
Pharmacogenetics*
Polymorphism, Single Nucleotide*
Treatment Outcome
Chemical
Reg. No./Substance:
0/ABCB1 protein, human; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Organic Anion Transporters; 0/P-Glycoprotein; 0/SLCO1B1 protein, human

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