Document Detail


Pharmacogenetic analysis in the treatment of Hodgkin's lymphoma.
MedLine Citation:
PMID:  23323945     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract About 15-20% of patients with Hodgkin's lymphoma (HL) treated with ABVD chemotherapy ± radiotherapy still die following relapse or progressive disease. Outcome might be influenced by gene polymorphisms influencing chemotherapy metabolism. We studied 126 patients with HL treated with ABVD regimen. We analyzed glutathione S-transferases (GSTT1, GSTM1 and GSTP1), cytochromes P450 (CYP3A4, CYP2D6), UGT1A1 and BLMH gene polymorphisms and their association with clinical and outcome variables. Patients with a GSTM1 genotype associated with extensive or ultrahigh activity had a probability of 93.8% to achieve complete response, while the rest of the patients had a probability of 82.3% (P=0.04). This variable maintained its statistical significance in multivariate analysis (HR 3.7, CI 95% 1 - 13, p= 0.05). Patients with an extensive or ultrahigh GSTM1 genotype had better prognostic factors than those with poor or intermediate genotypes (Hb level, P=0.003; serum albumin, P=0.05; and IPS, P=0.038). Thus, in the treatment of HL, clinical determinants might be more relevant than the pharmacogenetic parameters analyzed to date.
Authors:
Albert Altés; Laia Paré; Albert Esquirol; Blanca Xicoy; Elena Rámila; Laura Vicente; Rosario López; Jaume Orriols; Ferran Vall-Llovera; Blanca Sánchez-González; Elisabeth Del Río; Anna Sureda; David Páez; Montserrat Baiget
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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