Document Detail


Pharmacoeconomic impact of once-daily aminoglycoside administration.
MedLine Citation:
PMID:  9250562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective cost analysis compared hospital costs of standard gentamicin dosing and once-daily regimens in 1127 patients. Hospital costs compared were drug/supply/preparation/administration (DSPA; $4.56/500 mg once-daily dose and $3.32/100 mg every 8 hrs standard dose); therapeutic drug monitoring (TDM) ($25/gentamicin level); and nephrotoxicity management. The mean length of therapy was 4.5 days with both regimens. The mean number of blood samples drawn to measure drug levels was 0.65 for once-daily dosing and 1.7 for standard dosing. Mean DSPA and TDM costs/patient for a 4.5-day course of once-daily therapy were $20.52 and $16.25, respectively ($36.77/course of therapy). In comparison, estimated mean DSPA and TDM costs for 4.5 days standard therapy were $44.82 and $42.50, respectively ($87.32/course of therapy). We observed an overall reduction in nephrotoxicity from approximately 4% to 1.2% with the once-daily program, resulting in a nephrotoxicity management cost reduction from $182 to $55/patient exposed to aminoglycosides. The once-daily program resulted in a 58% reduction in aminoglycoside-associated hospital cost and a nephrotoxicity management savings of 70%/patient.
Authors:
C M Hitt; M E Klepser; C H Nightingale; R Quintiliani; D P Nicolau
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  17     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-25     Completed Date:  1997-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  810-4     Citation Subset:  IM    
Affiliation:
Hospital Pharmacy Services, Mayo Medical Center, Rochester, Minnesota 55902, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage,  adverse effects,  economics*
Costs and Cost Analysis
Economics, Hospital
Gentamicins / administration & dosage,  economics*
Hospitals
Humans
Kidney Diseases / economics,  prevention & control
Minnesota
Retrospective Studies
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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