Document Detail


Pharmacoeconomic Spotlight on Rotavirus Vaccine RIX4414 (Rotarix™) in the Prevention of Rotavirus Gastroenteritis in Developing Countries†
MedLine Citation:
PMID:  23013458     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This article provides an overview of the clinical profile of rotavirus vaccine RIX4414 (Rotarix™) in the prevention of rotavirus gastroenteritis (RVGE) in developing countries, followed by a review of pharmacoeconomic analyses with the vaccine in low- and middle-income countries. RVGE is associated with significant morbidity and mortality among children <5 years of age in developing countries. The protective efficacy of a two-dose oral series of rotavirus vaccine RIX4414 has been demonstrated in several well designed clinical trials conducted in developing countries, and the 'real-world' effectiveness of the vaccine has also been shown in naturalistic and case-control trials after the introduction of universal vaccination programs with RIX4414 in Latin American countries. The WHO recommends universal rotavirus vaccination programs for all countries. Numerous modelled cost-effectiveness analyses have been conducted with rotavirus vaccine RIX4414 across a wide range of low- and middle-income countries. Although data sources and assumptions varied across studies, results of the analyses consistently showed that the introduction of the vaccine as part of a national vaccination program would be very cost effective compared with no rotavirus vaccination program, according to widely used cost-effectiveness thresholds for developing countries. Vaccine price was not known at the time the analyses were conducted and had to be estimated. In sensitivity analyses, rotavirus vaccine RIX4414 generally remained cost effective at the highest of a range of possible vaccine prices considered. Despite these favorable results, decisions regarding the implementation of universal vaccination programs with RIX4414 may also be contingent on budgetary and other factors, underscoring the importance of subsidized vaccination programs for poor countries through the GAVI Alliance (formerly the Global Alliance for Vaccines and Immunization).
Authors:
Greg L Plosker
Related Documents :
23458088 - Supplementary immunization activities (sias) in south africa: comprehensive economic ev...
24001248 - Inviting free-riders or appealing to prosocial behavior? game-theoretical reflections o...
20649608 - British society for allergy and clinical immunology guidelines for the management of eg...
23965828 - Japanese encephalitis surveillance and immunization - asia and the western pacific, 2012.
3932248 - Evaluation of brucellin skin test for bovine brucellosis.
24440968 - Salmonella vaccines: lessons from the mouse model or bad teaching?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Paediatric drugs     Volume:  -     ISSN:  1179-2019     ISO Abbreviation:  Paediatr Drugs     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883685     Medline TA:  Paediatr Drugs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Adis, Auckland, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phantom Limb Pain in Daily Practice-Still a Lot of Work to Do!
Next Document:  When to Start, What to Start and Other Treatment Controversies in Pediatric HIV Infection.