Document Detail


Pharmacodynamics of oestrogens and progestogens.
MedLine Citation:
PMID:  10997774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ovaries cyclically secrete estradiol and progesterone. Cyclic ovarian estradiol secretion is associated with a bone-saving and vascular protection effect. Endogenous progesterone does not modify the vasodilator effect of oestrogens. At physiological concentrations, the natural sex steroids have low antigonadotropic effects. More potent synthetic derivatives with more antigonadotropic effects were synthesized in the 1950s. After the menopause, there is no longer any need to use hormonal steroids as antigonadotropics. In addition, vascular contraindications are more common in an older population. Contraceptive steroids (particularly ethinyl estradiol) are therefore rarely used. The oestrogen that is most widely prescribed for post-menopausal replacement is a complex formulation of conjugated oestrogens of equine origin that is administered orally in a single daily dose. Improvements in hormone replacement therapy may result from the use of parenteral estradiol (providing sufficient doses are reached) and of a progestogen chemically more similar to progesterone.
Authors:
B de Lignières; S Silberstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  20     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2001-01-25     Completed Date:  2001-01-26     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  200-7     Citation Subset:  IM    
Affiliation:
Hôpital Necher, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Contraceptives, Oral / blood,  pharmacokinetics*
Estradiol / blood,  pharmacokinetics*
Estrogens / chemistry,  metabolism,  pharmacokinetics
Female
Hormone Replacement Therapy* / methods
Humans
Menopause / blood*
Progesterone / blood,  pharmacokinetics*
Progestins / chemistry,  metabolism,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Estrogens; 0/Progestins; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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