| Pharmacodynamics of non-replicating viruses, bacteriocins and lysins. | |
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MedLine Citation:
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PMID: 17015317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacodynamics of antibiotics and many other chemotherapeutic agents is often governed by a 'multi-hit' kinetics, which requires the binding of several molecules of the therapeutic agent for the killing of their targets. In contrast, the pharmacodynamics of novel alternative therapeutic agents, such as phages and bacteriocins against bacterial infections or viruses engineered to target tumour cells, is governed by a 'single-hit' kinetics according to which the agent will kill once it is bound to its target. In addition to requiring only a single molecule for killing, these agents bind irreversibly to their targets. Here, we explore the pharmacodynamics of such 'irreversible, single-hit inhibitors' using mathematical models. We focus on agents that do not replicate, i.e. in the case of phage therapy, we deal only with non-lytic phages and in the case of cancer treatment, we restrict our analysis to replication of incompetent viruses. We study the impact of adsorption on dead cells, heterogeneity in adsorption rates and spatial compartmentalization. |
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Authors:
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James J Bull; Roland R Regoes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Proceedings. Biological sciences / The Royal Society Volume: 273 ISSN: 0962-8452 ISO Abbreviation: Proc. Biol. Sci. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-12-14 Completed Date: 2007-02-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101245157 Medline TA: Proc Biol Sci Country: England |
Other Details:
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Languages: eng Pagination: 2703-12 Citation Subset: IM |
Affiliation:
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The Institute for Cellular and Molecular Biology, Section of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacokinetics Bacteriocins / pharmacokinetics* Models, Biological Mucoproteins / pharmacokinetics* Protein Binding Virus Replication Viruses / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM57756/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacteriocins; 0/Mucoproteins; 0/lysin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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