| Pharmacodynamics of the diuretic effects of aminophylline and acetazolamide alone and combined with furosemide in normal subjects. | |
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MedLine Citation:
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PMID: 6620175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current study was performed in normal subjects to assess the mechanism of the natriuretic effects of aminophylline, to confirm the effect of acetazolamide on the proximal tubule and to assess the pharmacodynamics of the combination of aminophylline and of acetazolamide with furosemide. None of these agents or their combination affected renal hemodynamics. Aminophylline inhibited solute reabsorption at the diluting segment manifested by a 15% decrease in free water clearance relative to solute delivery (P less than .001). In addition, it decreased solute reabsorption in the proximal nephron. Acetazolamide affected only the proximal tubule. The combination of either aminophylline or of acetazolamide with furosemide was little different from furosemide alone. Analysis of dose-response curves to furosemide revealed a minor additive, i.e., parallel upward shift, of the dose-response curves with both combinations. |
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Authors:
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D C Brater; S Kaojarern; P Chennavasin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 227 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 92-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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administration & dosage,
pharmacology* Aminophylline / administration & dosage, pharmacology* Diuretics* Dose-Response Relationship, Drug Drug Therapy, Combination Furosemide / administration & dosage* Humans Kidney / drug effects* Kidney Tubules, Proximal / drug effects Male Renal Circulation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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1-M01-RR00663/RR/NCRR NIH HHS; 5-R01-AM27059/AM/NIADDK NIH HHS; 5-T32-GM03247/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 317-34-0/Aminophylline; 54-31-9/Furosemide; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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