Document Detail

Pharmacodynamic interaction of eltanolone and alfentanil during lower abdominal surgery in female patients.
MedLine Citation:
PMID:  10618938     Owner:  NLM     Status:  MEDLINE    
We have studied the influence of eltanolone on intraoperative alfentanil requirements in 18 female patients undergoing lower abdominal surgery receiving target-controlled infusions of eltanolone and alfentanil. While target concentrations of eltanolone were maintained constant, target concentrations of alfentanil changed in response to the presence or absence of responses. With serum eltanolone concentrations increasing from 500 to 2000 ng ml-1, the EC50 of alfentanil for suppression of responses to surgical stimulation decreased from 233 to 9 ng ml-1. The findings suggest that the interaction between eltanolone and alfentanil is synergistic.
M J Mertens; J Vuyk; K Parivar; F H Engbers; A G Burm; J G Bovill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  83     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  250-2     Citation Subset:  IM    
Department of Anaesthesiology (P5), Leiden University Medical Centre, The Netherlands.
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MeSH Terms
Abdomen / surgery
Alfentanil / pharmacology*
Analgesics, Opioid / pharmacology*
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Synergism
Hypnotics and Sedatives / adverse effects,  pharmacology*
Middle Aged
Pregnanolone / pharmacology*
Urticaria / chemically induced
Reg. No./Substance:
0/Analgesics, Opioid; 0/Hypnotics and Sedatives; 128-20-1/Pregnanolone; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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