| Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high-fat diet induced hyperlipidemic rat model. | |
| | |
MedLine Citation:
|
PMID: 18787933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: It is believed that estrogen deficiency contributes importantly to the pathogenesis of menopausal metabolic syndrome and symptoms can be ameliorated with estradiol therapy. The present study reports efficacy of 17-beta estradiol encapsulated nanoparticles in treating the postmenopausal dyslipidemic condition. MATERIALS AND METHODS: Estradiol encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by emulsion-diffusion-evaporation method and evaluated in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model. RESULTS: The results obtained showed that estradiol nanoparticles were equally/more effective in treatment of estrogen deficient hyperlipidemic conditions at three times reduced dose and frequency in comparison to that of drug suspension administered orally. CONCLUSION: Together, these results demonstrate the ability of nanoparticles in improving oral bioavailability/efficacy of estradiol. |
| | |
Authors:
|
G Mittal; G Chandraiah; P Ramarao; M N V Ravi Kumar |
Related Documents
:
|
19359503 - Effect of graded levels of iron, zinc, and copper supplementation in diets with low-phy... 15539183 - Effect of thiamin deficiency on energy metabolites in the turkey. 20686513 - Dominant and diet-responsive groups of bacteria within the human colonic microbiota. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-12 |
Journal Detail:
|
Title: Pharmaceutical research Volume: 26 ISSN: 0724-8741 ISO Abbreviation: Pharm. Res. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-17 Completed Date: 2009-03-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: United States |
Other Details:
|
Languages: eng Pagination: 218-23 Citation Subset: IM |
Affiliation:
|
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholesterol / blood Diet Dietary Fats / pharmacology* Estradiol / administration & dosage*, pharmacology* Female Hyperlipidemias / metabolism* Lactic Acid Nanoparticles* Ovariectomy* Particle Size Polyglycolic Acid Rats Rats, Sprague-Dawley Thiobarbituric Acid Reactive Substances / metabolism Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Thiobarbituric Acid Reactive Substances; 0/Triglycerides; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 50-28-2/Estradiol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced a...
Next Document: Study of Protein-Probe Interaction and Protective Action of Surfactant Sodium Dodecyl Sulphate in Ur...