Document Detail


Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosis.
MedLine Citation:
PMID:  19105148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe the effects of iopanoic acid on daily levels of free triiodothyronine (FT(3)) and free thyroxine (FT(4)) in a patient with progressive type II amiodarone-induced thyrotoxicosis (AIT) who was undergoing thyroidectomy. The patient was a 59-year-old man who was undergoing amiodarone therapy while awaiting cardiac transplantation; the use of beta blockers and corticosteroids to control the AIT was contraindicated in this patient. Prior to thyroidectomy, the patient was started on iopanoic acid at 1.0 g twice a day; in response to gastrointestinal side effects, the dosage was subsequently reduced to 0.5 g twice a day. The patient responded to iopanoic acid with a rapid decrease in his FT(3) level and slight increase in his FT(4) level. This control of thyrotoxicosis allowed for an uneventful thyroidectomy, which was later followed by successful cardiac transplantation. Based on our findings in this single case, we believe that iopanoic can be used to rapidly lower FT(3) levels and to treat symptoms of thyrotoxicosis in a preoperative setting. We also discuss the different pharmacodynamic effects that iopanoic acid has on FT(3) and FT(4) levels.
Authors:
Laura Matrka; David Steward; Mercedes Falciglia; Yuri Nikiforov
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ear, nose, & throat journal     Volume:  87     ISSN:  1942-7522     ISO Abbreviation:  Ear Nose Throat J     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-05-08     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  7701817     Medline TA:  Ear Nose Throat J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  702-4     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0528, USA.
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MeSH Terms
Descriptor/Qualifier:
Amiodarone / adverse effects*
Atrial Fibrillation / drug therapy
Contrast Media
Humans
Iopanoic Acid / pharmacology*,  therapeutic use*
Male
Middle Aged
Thyroidectomy
Thyrotoxicosis / chemically induced*
Thyroxine / blood,  metabolism*
Triiodothyronine / blood,  metabolism*
Vasodilator Agents / adverse effects*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Vasodilator Agents; 1951-25-3/Amiodarone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 96-83-3/Iopanoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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