Document Detail

Pharmacodynamic assessment of a novel P2Y(12) receptor antagonist in Japanese patients with coronary artery disease undergoing elective percutaneous coronary intervention.
MedLine Citation:
PMID:  22178576     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Numerous reports have shown that prasugrel shows a rapid and consistent antiplatelet effect among European and US patients. Previous studies suggest that prasugrel might be expected to achieve an adequate antiplatelet effect in healthy Asian subjects, even at lower doses than those assessed in the TRITON-TIMI 38 study. In this study, the antiplatelet effect of prasugrel was evaluated in Japanese coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). METHODS AND RESULTS: Eighty-four patients were randomized into four treatment groups: prasugrel 10/2.5mg (loading dose [LD]/maintenance dose [MD]), 15/3.75mg or 20/5mg, and clopidogrel 300/75mg. The LD of each regimen was administered the day before PCI, followed by 28-day MD on aspirin background therapy (81-100mg). Antiplatelet effects were evaluated by light transmission aggregometry and VASP assay. The mean inhibition of platelet aggregation (IPA) induced by 20μM of adenosine diphosphate at 4hours after LD was higher among the prasugrel 10/2.5mg, 15/3.75mg and 20/5mg groups compared with the clopidogrel group (12.3%, 20.9%, 29.8% vs. 8.4%, respectively). The proportion of subjects with an IPA of <10% on Day 28 was lower among the prasugrel 15/3.75mg, and 20/5mg groups than in the clopidogrel group (0%, 6.3% vs. 15.8%, respectively). No "major" or "clinically relevant non-major" bleeding was observed. CONCLUSIONS: Prasugrel 15mg LD/3.75mg MD or higher doses was well tolerated and achieved a more rapid, higher and consistent antiplatelet effect than clopidogrel in Japanese CAD patients undergoing PCI.
Hiroyoshi Yokoi; Takeshi Kimura; Takaaki Isshiki; Hisao Ogawa; Yasuo Ikeda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-16
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Department of Cardiovascular Medicine, Kokura Memorial Hospital, Fukuoka, Japan.
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