Document Detail

Pharmacist review prevents evolving metformin-associated lactic acidosis.
MedLine Citation:
PMID:  24989238     Owner:  NLM     Status:  Publisher    
WHAT IS KNOWN: There is controversy surrounding the risk of metformin and the development of lactic acidosis. There have been no reports of a pharmacist preventing a patient developing metformin-associated lactic acidosis.
OBJECTIVES: Our objective was to report on a pharmacist potentially preventing an evolving case of metformin-associated lactic acidosis (MALA).
CASE DESCRIPTION: A patient who had been having episodes of nausea and vomiting for a year was referred for a home medicines review (HMR) by his general practitioner. The pharmacist who conducted the HMR suspected that the patient's symptoms could have been due to metformin. It was recommended to measure the serum lactate level and suspend metformin. Our patient was found to have a high lactate level and was referred to the emergency department by his general practitioner. Recovery was prompt with symptomatic support and cessation of metformin.
WHAT IS NEW: This appears to be the first case reported in the literature of a pharmacist recognizing an evolving case of MALA.
CONCLUSION: Although the incidence of MALA is rare, health professionals should be aware of the initial symptoms of lactic acidosis, especially in elderly patients with risk factors, to prevent a fatal lactic acidosis event.
M Naunton; G Kyle; F Owoka; K Naunton-Boom
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-3
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  -     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
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