| Pharmaceutical sponsorship bias influences thrombolytic literature in acute ischemic stroke. | |
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MedLine Citation:
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PMID: 22224134 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The efficacy of thrombolytic therapy for acute ischemic stroke remains controversial in emergency medicine and has not been fully endorsed by either the American College of Emergency Physicians or the American Academy of emergency medicine. A growing recognition exists of the influence of pharmaceutical sponsorship on the reported findings of published clinical trials. Sponsorship bias has been suggested as a potential criticism of the literature and guidelines favoring thrombolytic therapy. OBJECTIVE: The objective of this study is to review the most influential literature regarding thrombolytic therapy for acute ischemic stroke and document the presence or absence of pharmaceutical sponsorship. METHODS: A publication-citation analysis was performed to identify the most frequently cited articles pertaining to thrombolytic therapy for acute ischemic stroke. Identified articles were reviewed for disclosures of pharmaceutical funding. RESULTS: Of the 20 most-cited articles pertaining to thrombolytic therapy for acute stroke, 17 (85%) disclosed pharmaceutical sponsorship. These disclosures range from general sponsorship to direct employment of authors by pharmaceutical companies. CONCLUSION: An overwhelming predominance of the most influential literature regarding thrombolytic therapy for acute ischemic stroke is susceptible to sponsorship bias. This potential bias may provide a basis for physician concern regarding the efficacy and safety of thrombolytic therapy. Further, large, independent, placebo-controlled studies may be required to guide therapy and professional guidelines definitively for acute ischemic stroke. |
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Authors:
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Ryan Patrick Radecki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The western journal of emergency medicine Volume: 12 ISSN: 1936-9018 ISO Abbreviation: West J Emerg Med Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101476450 Medline TA: West J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 435-41 Citation Subset: - |
Affiliation:
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The University of Texas Health Science Center at Houston, Department of Emergency Medicine, Houston, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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