| Pharmaceutical metabolic down-regulation by protein synthesis inhibition in a conscious rat model. | |
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MedLine Citation:
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PMID: 17292527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmaceutically induced metabolic down-regulation may be a useful therapeutic adjunct when tissue oxygen supply is restricted. We hypothesized that protein synthesis inhibition in a non-hibernating species should lower oxygen demand, resulting in aerobic metabolic rate depression at the whole animal level. We compared metabolic responses and measures of systemic oxygenation of conscious catheterized rats given either protein synthesis inhibition (PSI) agents or carrier controls (normal saline and DMSO). Core temperature was measured by implanted transmitters, and VO2 was determined in an open flow-through metabolic chamber at 25 degrees C. Mean arterial pressure MAP and heart rate HR were determined from arterial pressure transducer tracings; arterial blood gases and lactate were sampled every 15 min. PSI rats exhibited an immediate transient decline in VO2, followed by a secondary decline to new resting levels; VO2 for the first hour was significantly lower than that for rats receiving DMSO vehicle. Unlike controls, PSI rats showed an overall 3.5 degrees C decline in core temperature, coupled with increased arterial lactate. There were no differences in MAP and HR of PSI rats compared to controls. Although hypothermic response to toxic agents typical of rodents cannot be ruled out completely, the mild hypothermia and reduced VO2 exhibited by PSI rats may be partially attributed to the action of protein synthesis agents. |
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Authors:
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Penny S Reynolds; R Wayne Barbee; Kevin R Ward |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-02-09 |
Journal Detail:
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Title: Resuscitation Volume: 73 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-08-17 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 446-58 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0401, USA. psreynolds@vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisomycin / pharmacology* Blood Gas Analysis Body Temperature / drug effects* Consciousness / drug effects Heart Rate / drug effects Male Motor Activity / drug effects Oxygen Consumption / drug effects* Protein Synthesis Inhibitors / pharmacology* Puromycin / pharmacology* Rats Rats, Sprague-Dawley Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Protein Synthesis Inhibitors; 22862-76-6/Anisomycin; 53-79-2/Puromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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