Document Detail


Phagocytosis of individual CD4+ T cells by HIV-induced T cell syncytia.
MedLine Citation:
PMID:  7632459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transmission electron microscopic analysis of HIV-induced syncytia of the CD4+ SupT1 cell line has revealed profiles of whole T cells in the syncytium cytoplasm. Serial sections demonstrate that these T cells are completely enveloped by a second membrane in the syncytium cytoplasm and represent phagosomes. Pycnosis of engulfed T cell nuclei, vacuolation of the cytoplasm of engulfed T cells, and the association of engulfed T cells with dense vesicular clusters in the syncytium cytoplasm support the conclusion that they represent phagosomes. In addition, transmission electron micrographs of the syncytium surface reveal giant pseudopodial extensions wrapping around T cells, in a fashion similar to bacterial and yeast phagocytosis by professional phagocytes. These results suggest that phagocytosis is a characteristic acquired during HIV-induced syncytium formation, and that it may represent an avenue of T cell death in addition to fusion in HIV-infected SupT1 cell cultures.
Authors:
S Murphy; A Sylwester; R C Kennedy; D R Soll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  11     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-14     Completed Date:  1995-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-42     Citation Subset:  IM; X    
Affiliation:
Department of Biological Sciences, University of Iowa, Iowa City 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes / immunology*,  ultrastructure
Cell Fusion
Cell Line
Cell Movement
Cytopathogenic Effect, Viral
Giant Cells / immunology*,  physiology,  ultrastructure
HIV-1 / pathogenicity*
Humans
Microscopy, Electron
Microscopy, Electron, Scanning
Phagocytosis*
Pseudopodia / immunology,  ultrastructure
Grant Support
ID/Acronym/Agency:
AI-26462/AI/NIAID NIH HHS; AI-28696/AI/NIAID NIH HHS; HD 18577/HD/NICHD NIH HHS

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