| Phagocytosis in patients with sickle cell disease. | |
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MedLine Citation:
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PMID: 6663606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty sickle cell disease (SCD) patients, homozygous for sickle hemoglobin, were studied during asymptomatic periods. After clinical evaluation, several peripheral phagocyte parameters were evaluated. These were: ingestion rate, percentage of phagocytes with ingested particles, nitro-blue-tetrazolium (NBT) reduction rate, candidacidal activity; as well as serum levels of total haemolytic complement activity (CH50); third and fourth complement components (C3 and C4). Our data show a significant decrease of all studied phagocytosis parameters in the presence of sickle serum which indicate that asymptomatic SCD patients have basically deficient phagocytosis due to serum factors. Nine of the same patients were also evaluated during and after a painful crisis. Our results indicate that a painful crisis is not associated with further abnormalities of phagocytosis in SCD patients. |
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Authors:
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D E Hernandez; N Gonzalez; R Rios; L Merchan; H Wuani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical & laboratory immunology Volume: 12 ISSN: 0141-2760 ISO Abbreviation: J Clin Lab Immunol Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1984-03-01 Completed Date: 1984-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7808987 Medline TA: J Clin Lab Immunol Country: ITALY |
Other Details:
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Languages: eng Pagination: 137-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Sickle Cell / immunology* Candida / physiology Child Complement System Proteins / analysis Female Hemoglobin SC Disease / immunology* Humans Male Middle Aged Phagocytosis |
| Chemical | |
Reg. No./Substance:
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9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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