Document Detail


Phagocytosis in patients with sickle cell disease.
MedLine Citation:
PMID:  6663606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty sickle cell disease (SCD) patients, homozygous for sickle hemoglobin, were studied during asymptomatic periods. After clinical evaluation, several peripheral phagocyte parameters were evaluated. These were: ingestion rate, percentage of phagocytes with ingested particles, nitro-blue-tetrazolium (NBT) reduction rate, candidacidal activity; as well as serum levels of total haemolytic complement activity (CH50); third and fourth complement components (C3 and C4). Our data show a significant decrease of all studied phagocytosis parameters in the presence of sickle serum which indicate that asymptomatic SCD patients have basically deficient phagocytosis due to serum factors. Nine of the same patients were also evaluated during and after a painful crisis. Our results indicate that a painful crisis is not associated with further abnormalities of phagocytosis in SCD patients.
Authors:
D E Hernandez; N Gonzalez; R Rios; L Merchan; H Wuani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  12     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-03-01     Completed Date:  1984-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Sickle Cell / immunology*
Candida / physiology
Child
Complement System Proteins / analysis
Female
Hemoglobin SC Disease / immunology*
Humans
Male
Middle Aged
Phagocytosis
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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