Document Detail


Phagocytosis: elegant complexity.
MedLine Citation:
PMID:  15894272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phagocytosis requires receptor-mediated recognition of particles, usually in the guise of infectious agents and apoptotic cells. Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic digestion of the internalized contents into component parts. Recent findings indicate that a simple paradigm of a single cognate receptor interaction that guides the phagosome to phagolysosome formation belies the complexity of combinatorial receptor recognition and diversity of phagosome function. In fact, phagosomes are comprised of hundreds of proteins that play a key role in deciphering the contents of the phagosome and in defining host response. In this review we discuss how the challenge of recognizing diverse molecular patterns is met by combinatorial interactions between phagocytic receptors. Furthermore, these combinations are dynamic and both sculpt the balance between a proinflammatory or anti-inflammatory response and direct phagosome diversity. We also indicate an important role for genetically tractable model organisms in defining key components of this evolutionarily conserved process.
Authors:
Lynda M Stuart; R Alan B Ezekowitz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Immunity     Volume:  22     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-16     Completed Date:  2005-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-50     Citation Subset:  IM    
Affiliation:
Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Antigen Presentation
Apoptosis
Autophagy
Humans
Immunity, Innate
Models, Immunological
Opsonin Proteins / immunology
Phagocytes / immunology,  microbiology,  physiology
Phagocytosis / immunology*,  physiology
Phagosomes / immunology,  physiology
Receptors, Cell Surface / physiology
Signal Transduction
Grant Support
ID/Acronym/Agency:
P01 AI 4420/AI/NIAID NIH HHS; R01 AI 42788/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Opsonin Proteins; 0/Receptors, Cell Surface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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