Document Detail


Phagocytosis and comparative innate immunity: learning on the fly.
MedLine Citation:
PMID:  18219310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phagocytosis, the engulfment of material by cells, is a highly conserved process that arose before the development of multicellularity. Phagocytes have a key role in embryogenesis and also guard the portals of potential pathogen entry. They discriminate between diverse particles through the array of receptors expressed on their surface. In higher species, arguably the most sophisticated function of phagocytes is the processing and presentation of antigens derived from internalized material to stimulate lymphocytes and long-lived specific immunity. Central to these processes is the generation of a phagosome, the organelle that forms around internalized material. As we discuss in this Review, over the past two decades important insights into phagocytosis have been gleaned from studies in the model organism Drosophila melanogaster.
Authors:
Lynda M Stuart; R Alan Ezekowitz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  8     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-02-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  IM    
Affiliation:
Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02144, USA. lstuart@partners.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila melanogaster / immunology*
Immunity, Innate*
Phagocytosis*

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