Document Detail

Phagocytosis of blood cells by splenic macrophages in thrombotic thrombocytopenic purpura.
MedLine Citation:
PMID:  1169901     Owner:  NLM     Status:  MEDLINE    
A 43-year-old woman who developed thrombotic thrombocytopenic purpura was treated successfully with high doses of prednisone and a splenectomy. Imprints from the cut surface of the spleen showed marked phagocytosis of all the cellular elements of the blood. This observation suggests that hypersplenism, in addition to vascular occlusion, may play a major role in the physiopathology of some cases of thrombotic thrombocytopenic purpura.
A Kadri; M Noinuddin; N K de Leeuw
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  82     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-802     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Cells / immunology*
Chromium Radioisotopes / diagnostic use
Macrophages / immunology*
Prednisone / therapeutic use
Purpura, Thrombotic Thrombocytopenic / complications,  immunology*,  therapy
Seizures / etiology
Spleen / pathology
Splenomegaly / etiology
Reg. No./Substance:
0/Chromium Radioisotopes; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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