| Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C. | |
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MedLine Citation:
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PMID: 8457605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemozoin (malarial pigment) is a ferriprotoporphyrin IX-rich hemoglobin degradation product present in parasitized RBC. Avidly phagocytosed hemozoin abolishes phagocyte TPA-induced oxidative burst. Membrane-associated PKC increased transiently in hemozoin-fed monocytes by 50% after 30 min and decreased irreversibly to 20% of initial value within 5 h after phagocytosis. Control RBC-fed monocytes showed transient decay of membrane-associated PKC followed by complete recovery 12 h after phagocytosis. Cytosolic PKC was not impaired within 12 h and diminished drastically 24 h after phagocytosis of hemozoin. Results are compatible with increased degradation of membrane-translocated PKC, possibly by iron/H2O2-mediated damage of cysteine-rich regulatory domains of PKC. |
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Authors:
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E Schwarzer; F Turrini; G Giribaldi; M Cappadoro; P Arese |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1181 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-27 Completed Date: 1993-04-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 51-4 Citation Subset: IM |
Affiliation:
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Dipartimento di Genetica, Biologia, Chimica Medica, Università di Torino, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Hemeproteins / metabolism*, pharmacology Humans Monocytes / drug effects, enzymology*, immunology Phagocytosis* Pigments, Biological / metabolism*, pharmacology Plasmodium falciparum / immunology*, metabolism Protein Kinase C / antagonists & inhibitors* Respiratory Burst |
| Chemical | |
Reg. No./Substance:
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0/Hemeproteins; 0/Pigments, Biological; 39404-00-7/hemozoin; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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