Document Detail


Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C.
MedLine Citation:
PMID:  8457605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemozoin (malarial pigment) is a ferriprotoporphyrin IX-rich hemoglobin degradation product present in parasitized RBC. Avidly phagocytosed hemozoin abolishes phagocyte TPA-induced oxidative burst. Membrane-associated PKC increased transiently in hemozoin-fed monocytes by 50% after 30 min and decreased irreversibly to 20% of initial value within 5 h after phagocytosis. Control RBC-fed monocytes showed transient decay of membrane-associated PKC followed by complete recovery 12 h after phagocytosis. Cytosolic PKC was not impaired within 12 h and diminished drastically 24 h after phagocytosis of hemozoin. Results are compatible with increased degradation of membrane-translocated PKC, possibly by iron/H2O2-mediated damage of cysteine-rich regulatory domains of PKC.
Authors:
E Schwarzer; F Turrini; G Giribaldi; M Cappadoro; P Arese
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1181     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-27     Completed Date:  1993-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Affiliation:
Dipartimento di Genetica, Biologia, Chimica Medica, Università di Torino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Hemeproteins / metabolism*,  pharmacology
Humans
Monocytes / drug effects,  enzymology*,  immunology
Phagocytosis*
Pigments, Biological / metabolism*,  pharmacology
Plasmodium falciparum / immunology*,  metabolism
Protein Kinase C / antagonists & inhibitors*
Respiratory Burst
Chemical
Reg. No./Substance:
0/Hemeproteins; 0/Pigments, Biological; 39404-00-7/hemozoin; EC 2.7.11.13/Protein Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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