| Phagocytic leukocytes and reactive oxygen species. | |
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MedLine Citation:
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PMID: 19224236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phagocytic leukocytes, when appropriately stimulated, display a respiratory burst in which they consume oxygen and produce superoxide anions. Superoxide is produced by the phagocyte NADPH-oxidase system which is a multiprotein complex that is dissociated in quiescent cells and is assembled into the functional oxidase following stimulation of these cells. Also associated with the respiratory burst is the generation of other reactive oxygen species. The identity of components of the NADPH-oxidase system and their interactions are known in considerable molecular detail. Understanding of the regulation of superoxide production is less well known. This review also points out the important role of microscopy in complementing biochemical studies to understand better the cell biology of the phagocyte respiratory burst. |
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Authors:
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John M Robinson |
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Publication Detail:
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Type: In Vitro; Journal Article; Review Date: 2009-02-18 |
Journal Detail:
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Title: Histochemistry and cell biology Volume: 131 ISSN: 1432-119X ISO Abbreviation: Histochem. Cell Biol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-10 Completed Date: 2009-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506663 Medline TA: Histochem Cell Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 465-9 Citation Subset: IM |
Affiliation:
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Department of Physiology and Cell Biology, Ohio State University, 304 Hamilton Hall, Columbus, OH 43210, USA. robinson.21@osu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans NADPH Oxidase / metabolism* Neutrophils / metabolism*, ultrastructure Oxygen / metabolism Oxygen Consumption / physiology Phagocytes / metabolism*, ultrastructure Reactive Oxygen Species / metabolism* Respiratory Burst / physiology* Superoxides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 11062-77-4/Superoxides; 7782-44-7/Oxygen; EC 1.6.3.1/NADPH Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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