Document Detail

Phaeohyphomycosis and onychomycosis due to Chaetomium spp., including the first report of Chaetomium brasiliense infection.
MedLine Citation:
PMID:  21466265     Owner:  NLM     Status:  MEDLINE    
Chaetomium species have been rarely described as aetiological agents of invasive and dermatomycotic infections in humans. The majority of cases have been reported within the last two decades. Treatment failed in most of these cases. In this paper we present two cases in which Chaetomium spp. can be clearly identified as an aetiological agent in pathological conditions. In the first report, we describe a new aetiological agent, Chaetomium brasiliense, which was implicated in a case of otitis externa in a patient with spinocellular carcinoma basis cranii. The patient had been repeatedly treated for relapsing otitis externa and had previously undergone surgery several times for otitis media. The fungal aetiology was confirmed by repeated positive culture and histologic studies. The second case involved onychomycosis with strikingly brown nail discoloration due to Chaetomium globosum in an otherwise healthy patient. The nail lesion was successfully cured by oral terbinafine. The determination of both species was supported by sequencing of rDNA regions. The morphological aspect of Chaetomium spp. identification is also discussed. In vitro antifungal susceptibility tests demonstrated that both isolates were susceptible to terbinafine and azole derivates except fluconazole. Amphotericin B was effective only against the C. brasiliense strain. We review the literature to summarize clinical presentations, histologic findings, and treatment strategies.
Vit Hubka; Karel Mencl; Magdalena Skorepova; Pavlina Lyskova; Eva Zalabska
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-05
Journal Detail:
Title:  Medical mycology     Volume:  49     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-06     Completed Date:  2012-01-10     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  724-33     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/FR718872;  FR718873;  FR823008;  FR823009
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MeSH Terms
Antifungal Agents / pharmacology
Chaetomium / classification,  genetics,  isolation & purification*
DNA, Fungal / chemistry,  genetics
DNA, Ribosomal / chemistry,  genetics
DNA, Ribosomal Spacer / chemistry,  genetics
Microbial Sensitivity Tests
Middle Aged
Molecular Sequence Data
Onychomycosis / diagnosis*,  microbiology*
Otitis Externa / diagnosis,  microbiology,  pathology
Phaeohyphomycosis / diagnosis*,  microbiology*,  pathology
Sequence Analysis, DNA
Reg. No./Substance:
0/Antifungal Agents; 0/DNA, Fungal; 0/DNA, Ribosomal; 0/DNA, Ribosomal Spacer

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