Document Detail

Phaeochromocytoma with normal urinary catecholamines: the potential value of urinary free metadrenalines.
MedLine Citation:
PMID:  12564837     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Normal urine catecholamine values in patients with phaeochromocytoma is an occasional finding and may lead to a missed diagnosis. Additional urinary free metadrenaline analysis may be of value in this situation. METHODS: In addition to vanillylmandelic acid, homovanillic acid and the catecholamines, urinary free normetadrenaline (fNMA) and free metadrenaline (fMA) were measured. This report describes six confirmed cases of phaeochromocytoma showing normal urinary catecholamine output and compares fMA results and tumour size with other confirmed cases where the urine catecholamines were increased. RESULTS: Urine catecholamines in these patients with, on average, smaller tumours, were all normal. Urinary fNMA and fMA were available on five patients, and were increased in three. The data suggest that, unlike the catecholamines, urinary fNMA and fMA could be a useful predictor of tumour size. CONCLUSION: The inclusion of fNMA and fMA in the test profile is likely to be of additional benefit in tumour detection, particularly when catecholamines or other metabolites are normal.
D Fraser Davidson
Related Documents :
8340227 - Influence of size of liposomes in potentiating the efficacy of encapsulated triethylene...
16535397 - Mechanism and regulation of isoleucine excretion in corynebacterium glutamicum.
3759427 - Diagnosis of acute cholecystitis by 99mtc-iminodiacetic acid cholescintigraphy.
2748997 - The effects of repeated parenteral administration of chelating agents on the distributi...
21711917 - General metabolism of laribacter hongkongensis: a genome-wide analysis.
23867087 - Application of isotope-based carboxy group derivatization in lc-ms/ms analysis of tissu...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  39     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-66     Citation Subset:  IM    
Biochemistry Department, Crosshouse Hospital, Kilmamock KA2 OBE, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Catecholamines / isolation & purification*,  urine*
Chromatography, High Pressure Liquid
Homovanillic Acid / metabolism
Metanephrine / urine
Middle Aged
Pheochromocytoma / diagnosis*,  pathology,  urine*
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Catecholamines; 306-08-1/Homovanillic Acid; 5001-33-2/Metanephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Receptor activator for nuclear factor kappaB ligand and osteoprotegerin: regulators of bone physiolo...
Next Document:  Temporal changes in maternal serum biochemical markers of trisomy 21 across the first and second tri...