Document Detail


Phaeochromocytoma with normal urinary catecholamines: the potential value of urinary free metadrenalines.
MedLine Citation:
PMID:  12564837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Normal urine catecholamine values in patients with phaeochromocytoma is an occasional finding and may lead to a missed diagnosis. Additional urinary free metadrenaline analysis may be of value in this situation. METHODS: In addition to vanillylmandelic acid, homovanillic acid and the catecholamines, urinary free normetadrenaline (fNMA) and free metadrenaline (fMA) were measured. This report describes six confirmed cases of phaeochromocytoma showing normal urinary catecholamine output and compares fMA results and tumour size with other confirmed cases where the urine catecholamines were increased. RESULTS: Urine catecholamines in these patients with, on average, smaller tumours, were all normal. Urinary fNMA and fMA were available on five patients, and were increased in three. The data suggest that, unlike the catecholamines, urinary fNMA and fMA could be a useful predictor of tumour size. CONCLUSION: The inclusion of fNMA and fMA in the test profile is likely to be of additional benefit in tumour detection, particularly when catecholamines or other metabolites are normal.
Authors:
D Fraser Davidson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  39     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-66     Citation Subset:  IM    
Affiliation:
Biochemistry Department, Crosshouse Hospital, Kilmamock KA2 OBE, UK. fraser.davidson@aaaht.scot.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Catecholamines / isolation & purification*,  urine*
Chromatography, High Pressure Liquid
Female
Homovanillic Acid / metabolism
Humans
Male
Metanephrine / urine
Middle Aged
Pheochromocytoma / diagnosis*,  pathology,  urine*
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Catecholamines; 306-08-1/Homovanillic Acid; 5001-33-2/Metanephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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