| Phaeochromocytoma with normal urinary catecholamines: the potential value of urinary free metadrenalines. | |
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MedLine Citation:
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PMID: 12564837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Normal urine catecholamine values in patients with phaeochromocytoma is an occasional finding and may lead to a missed diagnosis. Additional urinary free metadrenaline analysis may be of value in this situation. METHODS: In addition to vanillylmandelic acid, homovanillic acid and the catecholamines, urinary free normetadrenaline (fNMA) and free metadrenaline (fMA) were measured. This report describes six confirmed cases of phaeochromocytoma showing normal urinary catecholamine output and compares fMA results and tumour size with other confirmed cases where the urine catecholamines were increased. RESULTS: Urine catecholamines in these patients with, on average, smaller tumours, were all normal. Urinary fNMA and fMA were available on five patients, and were increased in three. The data suggest that, unlike the catecholamines, urinary fNMA and fMA could be a useful predictor of tumour size. CONCLUSION: The inclusion of fNMA and fMA in the test profile is likely to be of additional benefit in tumour detection, particularly when catecholamines or other metabolites are normal. |
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Authors:
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D Fraser Davidson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 39 ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2003-02-04 Completed Date: 2003-10-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: England |
Other Details:
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Languages: eng Pagination: 557-66 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Crosshouse Hospital, Kilmamock KA2 OBE, UK. fraser.davidson@aaaht.scot.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Catecholamines / isolation & purification*, urine* Chromatography, High Pressure Liquid Female Homovanillic Acid / metabolism Humans Male Metanephrine / urine Middle Aged Pheochromocytoma / diagnosis*, pathology, urine* Reference Values Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 306-08-1/Homovanillic Acid; 5001-33-2/Metanephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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