| Phaeochromocytoma in the Hong Kong Chinese population. | |
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MedLine Citation:
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PMID: 20683066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the clinical manifestations of phaeochromocytoma in a Hong Kong Chinese population. DESIGN: Retrospective review. SETTING. Five public hospitals in Hong Kong. PATIENTS: Seventeen patients with operated phaeochromocytoma between 1994 and 2003 were reviewed retrospectively. RESULTS: Six patients (35%) were men, 11 (65%) were women. The mean age at presentation was 47 (range, 17-72) years. The diagnosis post-presentation was delayed by 1 to 132 months. Over 70% of the patients had hypertension. The most frequent symptoms were headache (53%), palpitations (53%), and sweating (41%); all these symptoms were present in 24% of the patients. Four (24%) had hereditary phaeochromocytoma/paraganglioma syndrome. The sensitivity of 24-hour urinary catecholamine measurements was 82%. Mean urinary adrenaline and noradrenaline concentrations were respectively 7- and 8-fold greater than the upper reference limits. Computed tomography and metaiodobenzylguanidine scintigraphy were the most widely used means for tumour localisation (sensitivity, 100% and 87% respectively). Approximately 65% of the patients had intra-adrenal tumours; 53% were on right side, 18% were bilateral. All the patients were prescribed phenoxybenzamine (dosage range, 20-120 mg/day) preoperatively. Two thirds of the patients had improved blood pressure 1 year after the operation. No malignancy was reported after a mean follow-up period of 7 years. CONCLUSION: Our series of patients with phaeochromocytomas commonly had a high frequency of normotension and extra-adrenal tumours. A high index of clinical suspicion and appropriate biochemical investigations are necessary to make the diagnosis, especially for patients manifesting adrenal incidentaloma and extra-adrenal lesion. |
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Authors:
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Joyce S Y Yau; June K Y Li; Vicki H K Tam; L M Fung; C K Yeung; K W Chan; K M Lee; K F Lee; W S Cheung; Vincent T F Yeung; Y P Yuen; W K Kwan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine Volume: 16 ISSN: 1024-2708 ISO Abbreviation: Hong Kong Med J Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512509 Medline TA: Hong Kong Med J Country: China |
Other Details:
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Languages: eng Pagination: 252-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Yan Chai Hospital, Hong Kong. yauseeyun@yahoo.com.hk |
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use Adolescent Adrenal Gland Neoplasms / diagnosis, physiopathology*, therapy Adult Aged Catecholamines / urine Female Follow-Up Studies Hong Kong / epidemiology Humans Male Phenoxybenzamine / administration & dosage, therapeutic use Pheochromocytoma / diagnosis, physiopathology*, therapy Radiopharmaceuticals / diagnostic use Retrospective Studies Sensitivity and Specificity Time Factors Tomography, X-Ray Computed Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Radiopharmaceuticals; 59-96-1/Phenoxybenzamine; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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