Document Detail


Phaeochromocytoma in the Hong Kong Chinese population.
MedLine Citation:
PMID:  20683066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review the clinical manifestations of phaeochromocytoma in a Hong Kong Chinese population.
DESIGN: Retrospective review. SETTING. Five public hospitals in Hong Kong.
PATIENTS: Seventeen patients with operated phaeochromocytoma between 1994 and 2003 were reviewed retrospectively.
RESULTS: Six patients (35%) were men, 11 (65%) were women. The mean age at presentation was 47 (range, 17-72) years. The diagnosis post-presentation was delayed by 1 to 132 months. Over 70% of the patients had hypertension. The most frequent symptoms were headache (53%), palpitations (53%), and sweating (41%); all these symptoms were present in 24% of the patients. Four (24%) had hereditary phaeochromocytoma/paraganglioma syndrome. The sensitivity of 24-hour urinary catecholamine measurements was 82%. Mean urinary adrenaline and noradrenaline concentrations were respectively 7- and 8-fold greater than the upper reference limits. Computed tomography and metaiodobenzylguanidine scintigraphy were the most widely used means for tumour localisation (sensitivity, 100% and 87% respectively). Approximately 65% of the patients had intra-adrenal tumours; 53% were on right side, 18% were bilateral. All the patients were prescribed phenoxybenzamine (dosage range, 20-120 mg/day) preoperatively. Two thirds of the patients had improved blood pressure 1 year after the operation. No malignancy was reported after a mean follow-up period of 7 years.
CONCLUSION: Our series of patients with phaeochromocytomas commonly had a high frequency of normotension and extra-adrenal tumours. A high index of clinical suspicion and appropriate biochemical investigations are necessary to make the diagnosis, especially for patients manifesting adrenal incidentaloma and extra-adrenal lesion.
Authors:
Joyce S Y Yau; June K Y Li; Vicki H K Tam; L M Fung; C K Yeung; K W Chan; K M Lee; K F Lee; W S Cheung; Vincent T F Yeung; Y P Yuen; W K Kwan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine     Volume:  16     ISSN:  1024-2708     ISO Abbreviation:  Hong Kong Med J     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512509     Medline TA:  Hong Kong Med J     Country:  China    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Yan Chai Hospital, Hong Kong. yauseeyun@yahoo.com.hk
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine / diagnostic use
Adolescent
Adrenal Gland Neoplasms / diagnosis,  physiopathology*,  therapy
Adult
Aged
Catecholamines / urine
Female
Follow-Up Studies
Hong Kong / epidemiology
Humans
Male
Phenoxybenzamine / administration & dosage,  therapeutic use
Pheochromocytoma / diagnosis,  physiopathology*,  therapy
Radiopharmaceuticals / diagnostic use
Retrospective Studies
Sensitivity and Specificity
Time Factors
Tomography, X-Ray Computed
Young Adult
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Radiopharmaceuticals; 59-96-1/Phenoxybenzamine; 77679-27-7/3-Iodobenzylguanidine

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