Document Detail


Phadiatop testing in assessing predisposition to respiratory tract symptoms of allergic origin in athletes.
MedLine Citation:
PMID:  22554340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To validate the use of the Phadiatop test as a predictor of allergy-associated respiratory tract symptoms (RTS) in trail runners.
METHODS: The incidence of self-reported RTS was documented in 16 runners for 31 days and related to the Phadiatop status and circulating markers of allergic responses (changes in concentrations of serum IgE (sIgE), differential leucocyte counts) at 8 time points before, during and after a 3-day 95 km trail run.
RESULTS: Twelve (75%) athletes, of whom 7 (58%) were Phadiatoppositive, presented with post-race RTS. A peak sIgE concentration >100 IU/ml accompanied RTS in only 4 (57%) of the symptomatic Phadiatop-positive subjects. There was no significant difference between the eosinophil and basophil concentrations of the positive and negative groups (p>0.05). One Phadiatop-negative subject presented with RTS as well as a peak sIgE concentration >100 IU/ml.
CONCLUSION: The Phadiatop assay does not accurately predict the development of post-exercise RTS of allergic origin in trail runners.
Authors:
Anton H de Waard; Edith M Peters
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2012-03-22
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  102     ISSN:  0038-2469     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-11-19     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  309-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / diagnostic use
Asthma / diagnosis*
Female
Health Status
Humans
Hypersensitivity, Immediate / diagnosis*
Immunoglobulin E / blood*
Longitudinal Studies
Male
Middle Aged
Predictive Value of Tests
Running*
Sensitivity and Specificity
Young Adult
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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