| PhRMA white paper on ADME pharmacogenomics. | |
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MedLine Citation:
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PMID: 18524998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacogenomic (PGx) research on the absorption, distribution, metabolism, and excretion (ADME) properties of drugs has begun to have impact for both drug development and utilization. To provide a cross-industry perspective on the utility of ADME PGx, the Pharmaceutical Research and Manufacturers of America (PhRMA) conducted a survey of major pharmaceutical companies on their PGx practices and applications during 2003-2005. This white paper summarizes and interprets the results of the survey, highlights the contributions and applications of PGx by industrial scientists as reflected by original research publications, and discusses changes in drug labels that improve drug utilization by inclusion of PGx information. In addition, the paper includes a brief review on the clinically relevant genetic variants of drug-metabolizing enzymes and transporters most relevant to the pharmaceutical industry. |
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Authors:
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J Andrew Williams; Tommy Andersson; Tommy B Andersson; Rebecca Blanchard; Martin Otto Behm; Nadine Cohen; Timi Edeki; Monique Franc; Kathleen M Hillgren; Keith J Johnson; David A Katz; Mark N Milton; Bernard P Murray; Joseph W Polli; Deb Ricci; Lisa A Shipley; Subrahmanyam Vangala; Steven A Wrighton |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-06-04 |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 48 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 849-89 Citation Subset: IM |
Affiliation:
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Pfizer Global Research and Development, 10646 Science Center Drive (CB10), San Diego, CA 92121, USA. james.williams2@pfizer.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arylsulfotransferase
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genetics Catechol O-Methyltransferase / genetics Cytochrome P-450 Enzyme System / genetics Drug Design Drug Industry Drug Interactions Genotype Glucuronosyltransferase / genetics Humans Multidrug Resistance-Associated Proteins / genetics Pharmacogenetics* Pharmacokinetics* Polymorphism, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Multidrug Resistance-Associated Proteins; 0/multidrug resistance-associated protein 2; 9035-51-2/Cytochrome P-450 Enzyme System; EC 2.1.1.6/Catechol O-Methyltransferase; EC 2.4.1.-/bilirubin uridine-diphosphoglucuronosyl transferase 1A1; EC 2.4.1.17/Glucuronosyltransferase; EC 2.8.2.1/Arylsulfotransferase; EC 2.8.2.1/SULT1A1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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