Document Detail

Ph-negative chronic myeloid leukaemia.
MedLine Citation:
PMID:  3476149     Owner:  NLM     Status:  MEDLINE    
An analysis of five patients with Philadelphia chromosome (Ph) negative chronic myeloid leukaemia (CML) revealed that two were clinically and haematologically identical to Ph-positive CML whereas three should be reclassified as chronic myelomonocytic leukaemia (CMML). At a molecular level the first two patients showed the same juxtaposition of c-abl and bcr genes as is seen in Ph-positive CML. These genomic changes were not seen in the other three patients. Observations on these five patients suggest that the clinical course and prognosis of the rare patient who carries the Ph 'molecular defect' but lacks the Philadelphia chromosome is no different from Ph-positive CML.
P H Fitzgerald; M E Beard; C M Morris; D C Heaton; A E Reeve
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  66     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-09     Completed Date:  1987-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
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MeSH Terms
Chromosome Mapping
Leukemia, Myeloid / genetics*,  pathology
Middle Aged
Philadelphia Chromosome*

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