Document Detail

Peyronie's disease compromises the durability and component-malfunction rates in patients implanted with an inflatable penile prosthesis.
MedLine Citation:
PMID:  20128775     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the durability and complication rates of surgery to implant an inflatable penile prosthesis (IPP) between patients with and without Peyronie's disease (PD).
PATIENTS AND METHODS: We retrospectively reviewed all patients undergoing IPP surgery at one centre (Memphis) between July 1997 and May 2007. Variables included age at surgery, race, body mass index, presence of PD, brand/type of IPP (two vs three pieces), presence of diabetes mellitus (DM), active tobacco use, and complications. The result were assessed using t-tests, chi-square and regression analysis, with P < 0.05 considered to indicate significant differences.
RESULTS: In all, 79 men were analysed (mean age 59.8 years, range 38.1-81.5). Nine (11%) patients had PD and had a IPP implanted, with penile modelling. Overall, 43 (54%) patients had pre-existing DM and 51 (65%) actively used tobacco. At a mean (range) follow-up of 19.6 (0.1-115.3) months, six (8%) patients had component malfunctions. Of these, three had DM and four actively smoked. Of the nine patients with PD, three developed component malfunctions, vs three (4%) who did not have PD (P= 0.002). Both groups had similar infection rates (P= 0.98). The mean (range) time to component malfunction was 4.3 (0.1-9.6) months, which was longer (but not significantly) in the PD group, with a mean (median, range) of 10.9 (6.3, 1.1-9.6) months, than the 3.0 (1.0, 0.2-7.9) months in the group without PD (P= 0.4). Groups were matched for rates of DM (P= 0.1) and tobacco use (P= 0.2). PD was a significant predictor of component malfunction on both univariate (P= 0.001) and multivariate analysis (P= 0.002) when adjusting for age (P= 0.2), body mass index (P= 0.7), DM (P= 0.3) and tobacco use (P= 0.8).
CONCLUSION: Patients with PD implanted with a IPP, with penile modelling, had significantly higher component malfunction rates. Further, PD independently predicted component malfunction. These findings might be related to stress on the device at the time of surgery, during use, or both. Further study into this relationship is required.
Christopher J DiBlasio; Jordan M Kurta; Sisir Botta; John B Malcolm; Jim Y Wan; Ithaar H Derweesh; Michael A Aleman; Robert W Wake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJU international     Volume:  106     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  691-4     Citation Subset:  IM    
Copyright Information:
Department of Urology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
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MeSH Terms
Epidemiologic Methods
Erectile Dysfunction / etiology,  physiopathology,  surgery*
Middle Aged
Penile Implantation / methods*
Penile Induration / complications,  physiopathology,  surgery*
Penile Prosthesis*
Prosthesis Failure / etiology*
Smoking / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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