Document Detail


Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease.
MedLine Citation:
PMID:  17057202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical observations suggest that the sites of initial inflammation in ileal Crohn's disease (CD) are the lymphoid follicles, where the aphtoid lesions originate from small erosions of the follicle-associated epithelium (FAE). Lymphoid follicles and Peyer's patches (PPs) consist of a number of B-cell follicles with intervening T cell areas. The T cell follicular area is also populated by dendritic cells (DCs) and macrophages. A single layer of epithelial cells covering each follicle forms a dome between the surrounding villi. This FAE differs from normal villus epithelium in several ways that make the epithelial cells of the FAE more exposed to the luminal contents, more accessible to antigens, and in closer contact with the immune system. The most prominent feature is the presence of specialized M cells, which are optimized for antigen adherence and transport. M cells play an important role in the surveillance of the intestinal lumen, but also provide a route of entry for various pathogens. In this article we review the current knowledge on the epithelial phenotype of the human FAE, and changes of the FAE and M cells in intestinal inflammation, leading to a hypothesis of the role of the FAE and M cells in the pathogenesis of CD.
Authors:
Elisabet Gullberg; Johan D Söderholm
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1072     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218-32     Citation Subset:  IM    
Affiliation:
Colorectal Surgery Unit, Department of Surgery, University Hospital, SE-581 85 Linköping, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Crohn Disease / immunology*,  pathology
Disease Models, Animal
Humans
Immunity, Mucosal
Inflammation / immunology*
Intestinal Mucosa / immunology*,  microbiology,  physiopathology
Mice
Models, Immunological
Peyer's Patches / immunology*,  physiopathology

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