| Peutz-Jeghers syndrome and management recommendations. | |
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MedLine Citation:
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PMID: 16616343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease caused by germline mutation of the serine threonine kinase 11 and characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous melanin pigmentation. Patients with PJS are at increased risk for common and unusual types of gastrointestinal and nongastrointestinal tumors. This review analyzes currently available literature and describes the clinical characteristics of PJS, assesses the risk of malignancy in this disorder, and delineates management and surveillance recommendations for affected individuals. |
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Authors:
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Francis M Giardiello; Jill D Trimbath |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 4 ISSN: 1542-3565 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-17 Completed Date: 2006-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 408-15 Citation Subset: IM |
Affiliation:
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Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Neoplasms / etiology Peutz-Jeghers Syndrome / etiology, pathology*, therapy* Protein-Serine-Threonine Kinases / genetics Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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5P50CA062924/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.1.-/STK11 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
Comment In:
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Clin Gastroenterol Hepatol. 2006 Dec;4(12):1550; author reply 1550
[PMID:
17162246
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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