Document Detail

Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature.
MedLine Citation:
PMID:  3308369     Owner:  NLM     Status:  MEDLINE    
Three cases of Peutz-Jeghers polyposis with carcinoma of the digestive organs are studied. Although mucocutaneous pigmentation was not present in two of the three patients, the features of intestinal polyposis are consistent with those of Peutz-Jeghers syndrome. One patient had a carcinoma of the pancreas and the other two had carcinomas with colonic Peutz-Jeghers polyps. Previous reports on carcinomas associated with Peutz-Jeghers syndrome are reviewed. An unusual location in the gastrointestinal tract, together with occurrence at an early age, characterize the carcinoma in Peutz-Jeghers syndrome. In Japanese patients, the large bowel is the site of the greatest number of carcinomas. On the other hand, Western patients showed a relatively even distribution. A possible surveillance protocol for early detection of gastrointestinal carcinoma in patients with Peutz-Jeghers syndrome is discussed.
F Konishi; N E Wyse; T Muto; T Sawada; Y Morioka; H Sugimura; K Yamaguchi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  30     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-20     Completed Date:  1987-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  790-9     Citation Subset:  IM    
First Department of Surgery, University of Tokyo, Japan.
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MeSH Terms
Adenocarcinoma / pathology*,  surgery
Digestive System Neoplasms / pathology*,  surgery
Middle Aged
Neoplasms, Multiple Primary / pathology*
Peutz-Jeghers Syndrome / pathology*,  surgery
Risk Factors

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