| Pet keeping and tobacco exposure influence CD14 methylation in childhood. | |
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MedLine Citation:
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PMID: 23194293 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Several CD14 gene-environment interactions in relation to the development of allergic diseases have been reported, but the underlying biological mechanisms are unclear. We recently showed that CD14 methylation increased during childhood, parallelling a decreased impact of CD14 polymorphisms on soluble CD14 levels. Here, we aim to explore whether environmental stimuli during childhood affects CD14 methylation, thereby providing a biological mechanism through which environment may modulate genetic effect. METHODS: CD14 methylation levels were quantified in 157 children from the prospective Environment and Childhood Asthma birth cohort at ages 2 and 10. Associations between CD14 methylation levels and house dust levels of endotoxin, β(1,3)-glucans (at 2 yr only), allergens (dog, cat, and house dust mite), pet keeping and tobacco smoke exposure (TSE; questionnaire data) at 2 and 10 yr were explored. RESULTS: Children in homes without pets had larger increases in CD14 methylation through childhood (2-10 yr) compared with children with pets (2.1% increase (p = 0.003) vs. 0.4% decrease (n.s.), global p = 0.04). At 10 yr of age, lower CD14 methylation values were found in children with pets compared with children without pets at both 2 and 10 yr (5.4% vs. 7.5% [p = 0.02]). A similar trend was detected for TSE; children not exposed show larger increases in CD14 methylation, most pronounced in school-age girls exposed vs. not exposed to tobacco (5.5% vs. 7.5% methylation, p = 0.037). CONCLUSION: Pet keeping and TSE appears to limit increase in CD14 methylation from 2 to 10 yr of age. This may partly explain the diverging CD14 allele associations with allergic diseases detected in different environments. |
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Authors:
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Monica Cheng Munthe-Kaas; Randi J Bertelsen; Tale Maehre Torjussen; Hanne Sagsveen Hjorthaug; Dag E Undlien; Robert Lyle; Kristina Gervin; Berit Granum; Petter Mowinckel; Kai Håkon Carlsen; Karin C Lødrup Carlsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 23 ISSN: 1399-3038 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: 747-54 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Department of Pediatrics, Oslo University Hospital, Oslo, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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