Document Detail


Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.
MedLine Citation:
PMID:  12546819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate. Remaining ones show deficient expression of genes required for 5-HT synthesis, uptake, and storage. Significantly, defective development of the 5-HT system is followed by heightened anxiety-like and aggressive behavior in adults. These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior.
Authors:
Timothy J Hendricks; Dmitry V Fyodorov; Lauren J Wegman; Nadia B Lelutiu; Elizabeth A Pehek; Bryan Yamamoto; Jerry Silver; Edwin J Weeber; J David Sweatt; Evan S Deneris
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  37     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-04-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-47     Citation Subset:  IM    
Affiliation:
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Aggression / physiology*
Alleles
Animals
Anxiety / genetics*
Behavior, Animal / physiology
Biogenic Monoamines / biosynthesis
Carrier Proteins / biosynthesis,  genetics
Cell Differentiation / physiology
Chromatography, High Pressure Liquid
Immunohistochemistry
In Situ Hybridization
Membrane Glycoproteins / biosynthesis,  genetics
Membrane Transport Proteins*
Mice
Mice, Knockout
Nerve Tissue Proteins*
Nervous System / embryology
Neurons / physiology*
Postural Balance / physiology
Rhombencephalon / physiology
Serotonin / biosynthesis,  metabolism,  physiology*
Serotonin Plasma Membrane Transport Proteins
Transcription Factors / genetics*
Grant Support
ID/Acronym/Agency:
MH58926/MH/NIMH NIH HHS; MH62723/MH/NIMH NIH HHS; NS29123/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 0/Carrier Proteins; 0/Fev protein, mouse; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Serotonin Plasma Membrane Transport Proteins; 0/Slc6a4 protein, mouse; 0/Transcription Factors; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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