Document Detail

Pesticide residue analysis and its relationship to hazard characterisation (ADI/ARfD) and intake estimations (NEDI/NESTI).
MedLine Citation:
PMID:  12400449     Owner:  NLM     Status:  MEDLINE    
Over 800 pesticides are currently approved for use in one or more EU countries. The maximum residue levels (MRL) for agricultural pesticides are derived from field trials conducted under good agricultural practice (GAP). The MRL is a legally enforceable limit related to GAP. The results from field trials would only be used to establish MRLs if the estimated intake of residues did not exceed the acceptable daily intake (ADI) or acute reference dose (ARfD). However, the MRL is not linked to the ADI or ARfD, and could result in intakes considerably below the ADI/ARfD. This disconnection between hazard characterisation (ADI/ARfD) and potential exposure assessment (MRL) means that risk characterisation of pesticide residues is less transparent than for other chemicals present in human food. Residue levels at or below the MRL would not give intakes that exceed the ADI/ARfD but, despite this, there is public concern over such residues. Residue levels above the MRL have to be analysed on a case-by-case basis to determine if the intake could exceed the health-based limits. Other causes of public concern, such as the presence of multiple residues, are currently under investigation.
Andrew G Renwick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pest management science     Volume:  58     ISSN:  1526-498X     ISO Abbreviation:  Pest Manag. Sci.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2003-03-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100898744     Medline TA:  Pest Manag Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1073-82     Citation Subset:  IM    
Clinical Pharmacology Group, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK.
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MeSH Terms
Environmental Exposure / analysis*
Environmental Monitoring / methods
Hazardous Substances / analysis,  toxicity*
Models, Biological
No-Observed-Adverse-Effect Level
Pesticide Residues / analysis,  toxicity*
Risk Assessment / methods*
Toxicity Tests
Reg. No./Substance:
0/Hazardous Substances; 0/Pesticide Residues

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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