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Pesticide appliers, biocides, and birth defects in rural Minnesota.
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MedLine Citation:
PMID:  8732949     Owner:  NLM     Status:  MEDLINE    
Earlier studies by our group suggested the possibility that offspring of pesticide appliers might have increased risks of birth anomalies. To evaluate this hypothesis, 935 births to 34,772 state-licensed, private pesticide appliers in Minnesota occurring between 1989 and 1992 were linked to the Minnesota state birth registry containing 210,723 live births in this timeframe. The birth defect rate for all birth anomalies was significantly increased in children born to private appliers. Specific birth defect categories, circulatory/respiratory, urogenital, and musculoskeletal/integumental, showed significant increases. For the general population and for appliers, the birth anomaly rate differed by corp-growing region. Western Minnesota, a major wheat, sugar beet, and potato growing region, showed the highest rate of birth anomalies per/1000 live births: 30.0 for private appliers versus 26.9 for the general population of the same region. The lowest rates, 23.7/1000 for private appliers versus 18.3/1000 for the general population, occurred in noncorp regions. The highest frequency of use of chlorophenoxy herbicides and fungicides also occurred in western Minnesota. Births in the general population of western Minnesota showed a significant increase in birth anomalies in the same three birth anomaly categories as appliers and for central nervous system anomalies. This increase was most pronounced for infants conceived in the spring. The seasonal effect did not occur in other regions. The male/female sex ratio for the four birth anomaly categories of interest in areas of high phenoxy herbicide/fungicide use is 2.8 for appliers versus 1.5 for the general population of the same region (p = 0.05). In minimal use regions, this ratio is 2.1 for appliers versus 1.7 for the general population. The pattern of excess frequency of birth anomalies by pesticide use, season, and alteration of sex ratio suggests exposure-related effects in appliers and the general population of the crop-growing region of western Minnesota.
V F Garry; D Schreinemachers; M E Harkins; J Griffith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  104     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-9     Citation Subset:  IM    
University of Minnesota Laboratory of Environmental Medicine and Pathology, Minneapolis 55414, USA.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology*
Fungicides, Industrial / toxicity
Herbicides / toxicity
Infant, Newborn
Minnesota / epidemiology
Occupational Exposure
Pesticides / toxicity*
Risk Factors
Rural Population
Reg. No./Substance:
0/Fungicides, Industrial; 0/Herbicides; 0/Pesticides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 4 Year: 1996
Volume: 104 Issue: 4
First Page: 394 Last Page: 399
ID: 1469337
PubMed Id: 8732949

Pesticide appliers, biocides, and birth defects in rural Minnesota.
V F Garry
D Schreinemachers
M E Harkins
J Griffith
University of Minnesota Laboratory of Environmental Medicine and Pathology, Minneapolis 55414, USA.

Article Categories:
  • Research Article

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