Document Detail

Pertussis in young infants: apnoea and intra-familial infection.
MedLine Citation:
PMID:  17328729     Owner:  NLM     Status:  MEDLINE    
This study investigated 41 infants, aged <4 months, who were hospitalised with symptoms compatible with pertussis. Of these, 16 had Bordetella pertussis infection confirmed by real-time PCR. For four of these 16 patients, the initial sample was PCR-negative, but samples collected 5-7 days after the onset of infection were PCR-positive. PCR was also positive with samples from 15/16 families and 20/41 household contacts. Nine of the 20 positive household contacts were asymptomatic. Among the 16 infants with proven pertussis, apnoea was more frequent than in a control group for whom PCR was negative with both children and household contacts (69% vs. 28%). It was concluded that real-time PCR performed with samples from household contacts facilitates the diagnosis of infants suspected clinically of having pertussis, thereby enabling earlier treatment.
J Raymond; J-B Armengaud; C Cosnes-Lambe; M Chalumeau; E Bosdure; H Reglier-Poupet; M-J El Hajje; J-L Iniguez; F Moulin; C Poyart; D Gendrel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  13     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  IM    
Laboratoire de Bacteriologie, Université Paris 5, Hôpital Saint Vincent de Paul-Cochin, Paris, France.
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MeSH Terms
Apnea / microbiology*
Bordetella Infections / epidemiology*
Bordetella pertussis / genetics,  isolation & purification
Cross Infection / epidemiology*
Polymerase Chain Reaction
Whooping Cough / microbiology*

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