Document Detail

Perturbation of the activity of a single identified neuron affects long-term memory formation in a molluscan semi-intact preparation.
MedLine Citation:
PMID:  16449565     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the neural basis of operant conditioning in a semi-intact preparation of the pond snail, Lymnaea stagnalis. Lymnaea learns, via operant conditioning, to reduce its aerial respiratory behaviour in response to an aversive tactile stimulus to its open pneumostome. Here we report the successful conditioning of naïve semi-intact preparations to show ;learning in the dish' and long-term memory that persists for at least 18 h. The neurons that generate this behaviour are readily identifiable and, for the first time, we have recorded from a neuron during a training paradigm that leads to long-term memory formation in the same preparation. Specifically, we recorded from the respiratory neuron Right Pedal Dorsal 1 (RPeD1), which is part of the respiratory central pattern generator and initiates the aerial respiratory behaviour. Previous studies have shown that long-term memory of this behaviour results in reduced RPeD1 activity. In the present study, we demonstrate that preventing RPeD1 impulse activity between training sessions reduces the number of sessions needed to produce long-term memory in our semi-intact preparation.
M R Lowe; G E Spencer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  209     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  711-21     Citation Subset:  IM    
Department of Biological Sciences, Brock University, Ontario, Canada, L2S 3A1.
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MeSH Terms
Conditioning, Operant / physiology
Lymnaea / physiology*
Memory / physiology*
Motor Neurons / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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